Research
We are interested in studying the disease pathology of autism, schizophrenia, cancers and dental diseases. By integrating multi-omics data including whole-exome, whole-genome, and epigenetic data, our work aims to develop innovative computational approaches and apply existing analytical tools to uncover new biological insights.
Han S+*, Sun X+, Sloofman L+, Satterstrom FK, Xu X, Liang L, Knoblauch N, Sheng W, Zhao S, Nguyen TH, Wang G; Autism Sequencing Consortium; Buxbaum J, He X*. MIRAGE: a Bayesian rare variant association analysis method incorporating functional information of variants. Am J Hum Genet., Volume 113, Issue 1, 2026, Pages 168-183, ISSN 0002-9297, https://doi.org/10.1016/j.ajhg.2025.11.013. [link] [R package] [PDF]
Gousias, C., Alsuwaiyan, Z., Fial, A., Han, S., Tatakis, D.N., and Kofina, V.* Pre-Emptive Analgesia for Periodontal and Implant-Related Surgery: A Systematic Review and Meta-Analysis. J Clin Periodontol (2025). [link]
Shengtong Han*, Marieke Gilmartin, Wenhui Sheng, Victor X. Jin. Integrating rare variant genetics and brain transcriptome data implicates novel schizophrenia putative risk genes. Schizophrenia Research, Volume 276, 2025, Pages 205–213, ISSN 0920-9964. [link] [PDF]
Han, S*. Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes. Journal of Personalized Medicine, 2024, 14, 822. https://doi.org/10.3390/jpm14080822 [link]
Jump-seq: genome-wide capture and amplification of 5hmC sites
Lulu Hu+, Yuwen Liu+, Shengtong Han+, Lei Yang+, Xiaolong Cui, Yawei Gao, Qing Dai, Xingyu Lu, Xiaochen Kou, Yanhong Zhao, Wenhui Sheng, Shaorong Gao, Xin He, and Chuan He. Journal of the American Chemical Society, 2019, 141(22), 8694–8697. [PDF] [Link]
Identifying heterogeneous transgenerational DNA Methylation sites via clustering in Beta regression
Shengtong Han, Hongmei Zhang, Gabrielle A. Lockett, Nandini Mukherjee, John W. Holloway, Wilfried J.J. Karmaus. The Annals of Applied Statistics, 2015, 9, 2052-2072. [PDF][Link]
A Full Bayesian Approach for Boolean Genetic Network Inference
Shengtong Han, Raymond K. W. Wong, Thomas C. M. Lee, Linghao Shen, Shuo-Yen R. Li, Xiaodan Fan. PLoS ONE, 2014, 9(12): e115806. doi:10.1371/journal.pone. 0115806. [PDF][Link]